Acute interstitial nephritis caused by drugs is an increasingly recognized from of acute renal failure. Early recognition of the etiologic drug is important, since the renal failure is reversible after discontinuation of the drug and rarely may
be
irreversible if the drug is not stopped. Various NSAIDs may be cause a deterioration of renal function with broad clinical spectrums such as nephrotic syndrome, acute interstitial nephritis, acute renal failure, acute tubular necrosis, papillary
necrosis, acute glomerulitis and vasculitis. Fenoprofen appeared to the more nephrotoxic than other NSAIDs and resulted in multiple renal lesions in the same patient. We experienced a case of fenoprofen-induced acute interstitial nephritis. This
patient
is a 53 years old female who developed a generalized edema, heavy proteinuria and renal insufficiency after taking fenoprofen for eight months. Renal biopsy revealed Iymphocyte and plasma cell infiltration with focal fibrosis in the interstitium.
We
noted rapid recovery of renal function by hemodialysis and drug withdrawl. So we report a case of acute interstitial nephritis caused by fenoprofen with a review of the literature.
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